Game species occurring in the reserve include wildebeest, zebra, impala, reedbuck, waterbuck, bushbuck, bushpig, red, blue and grey duiker, hippopotamus, crocodile, large-spotted genet and the shy bushbaby.
Enseleni Nature Reserve consists of coastal grasslands and forest and the Nseleni river provides a freshwater habitat. For birding enthusiasts the reserve boasts several unusual or rare species, namely African finfoot, purple crested lourie, Pels fishing owl, white-eared barbet and three species of elusive nightjars, Mozambique, Fiery necked and European.
Game species occurring in the reserve include wildebeest, zebra, impala, reedbuck, waterbuck, bushbuck, bushpig, red, blue and grey duiker, hippopotamus, crocodile, large-spotted genet and the shy bushbaby.
No accommodation, camping or caravanning is available in the reserve, but lovely picnic sites are available. There are two trails in the reserve, which offer fantastic scenery and the opportunity to experience different parts of the reserve and to spot a variety of birds and animals. The Nkonkoni trail is 4.8 km and the Mvubu trail is 5.2 km in length.